abstract：:Metallothioneins (MTs) have demonstrated strong antioxidant properties, however the biological significance of their effect against hydroxyl radical toxicity remains unclear. We investigated the oxidation and turnover of renal MTs in MT-preinduced mice after an injection of ferric nitrilotriacetate (Fe-NTA). Incubatio...

journal_title：Chemico-biological interactions

authors： Min KS,Kishi N,Yamashita N,Tanaka K

更新日期：2012-01-05 00:00:00

abstract：:It has been detected that hepatic adenosine A(2A) receptors play an active role in the pathogenesis of hepatic fibrosis and suggest a novel therapeutic target in the treatment and prevention of hepatic cirrhosis. In this paper we examined if our new triazine derivative (IMT) can inhibit ethanol-induced activation of H...

journal_title：Chemico-biological interactions

authors： Szuster-Ciesielska A,Sztanke K,Kandefer-Szerszeń M

更新日期：2012-01-05 00:00:00

abstract：:Human leukocyte endothelial adhesion and transmigration occur in the early stage of the pathogenesis of atherosclerosis. Vascular endothelial cells are targeted by pro-inflammatory cytokines modulating many gene proteins responsible for cell adhesion, thrombosis and inflammatory responses. This study examined the pote...

journal_title：Chemico-biological interactions

authors： Lee ES,Choi JS,Kim MS,You HJ,Ji GE,Kang YH

更新日期：2011-10-15 00:00:00

abstract：:Methyl 3,5-dicaffeoyl quinate (MDQ) is a flavonoid glucoside found in several plants that scavenges 1,1-diphenyl-2-picrylhydrazyl (DPPH) free radicals and peroxynitrite, and inhibits the formation of cholesteryl ester hydroperoxide during the copper ion-induced oxidation of blood plasma in rats. In this study, MDQ inh...

journal_title：Chemico-biological interactions

authors： Hu W,Shen T,Wang MH

更新日期：2011-10-15 00:00:00

abstract：:The pathogenesis of hepatic fibrosis involves significant deposition of fibrilar collagen and other extracellular matrix proteins. It is a rather dynamic process of wound healing in response to a variety of persistent liver injury caused by factors such as ethanol intake, viral infection, drugs, toxins, cholestasis, a...

journal_title：Chemico-biological interactions

authors： Mormone E,George J,Nieto N

更新日期：2011-09-30 00:00:00

abstract：:It was estimated, in a rat model of moderate and relatively high chronic human exposure to cadmium (Cd), whether enhanced zinc (Zn) consumption may prevent Cd-induced liver injury and if the possible protective effect of this bioelement depends on its intake. For this purpose, the structure and function of the liver o...

journal_title：Chemico-biological interactions

authors： Rogalska J,Pilat-Marcinkiewicz B,Brzóska MM

更新日期：2011-09-30 00:00:00

abstract：:The study examined the effects of galangin (GA) on oxidative stress, inflammatory cytokine levels and nuclear factor-kappa B (NF-κB) activation in fructose-fed rat liver. Adult male albino Wistar rats were divided into 4 groups. Groups 1 and 4 received the control diet containing starch as the source of carbohydrate w...

journal_title：Chemico-biological interactions

authors： Sivakumar AS,Anuradha CV

更新日期：2011-09-05 00:00:00

abstract：:2,4,6-Triphenyldioxane-1,3 (TPD) is a highly effective species-specific inducer of CYP2В in rats. Several analogs of TPD were synthesized to verify a hypothesis that minor changes in the inducer structure can cause changes in induction abilities (R=H, cisTPD and transTPD; R=N(CH(3))(2), transpDMA; R=NO(2), transpNO(2)...

journal_title：Chemico-biological interactions

authors： Pustylnyak V,Yarushkin A,Kachaylo E,Slynko N,Lyakhovich V,Gulyaeva L

更新日期：2011-07-15 00:00:00

abstract：OBJECTIVES:Oxidative stress is one component of alcoholic liver disease (ALD) that is manifested in the peroxidation of cellular lipids producing the electrophile, 4-hydroxynonenal (4-HNE). This electrophile is proposed to modify essential cellular proteins resulting in loss of protein function and cellular homeostasis...

journal_title：Chemico-biological interactions

authors： Smathers RL,Galligan JJ,Stewart BJ,Petersen DR

更新日期：2011-06-30 00:00:00

abstract：:Benzene exposure is associated with acute myeloid leukemia (AML), myelodysplastic syndromes (MDS), and probably lymphoma and childhood leukemia. Biological plausibility for a causal role of benzene in these diseases comes from its toxicity to hematopoietic stem cells (HSC) or progenitor cells, from which all leukemias...

journal_title：Chemico-biological interactions

authors： Smith MT,Zhang L,McHale CM,Skibola CF,Rappaport SM

更新日期：2011-06-30 00:00:00

abstract：:Adverse drug reactions (ADRs) remain a major complication of drug therapy and can be classified as 'on-target' or 'off-target' (idiosyncratic) reactions. On-target reactions can be predicted from the known primary or secondary pharmacology of the drug and often represent an exaggeration of the pharmacological effect o...

journal_title：Chemico-biological interactions

authors： Park BK,Laverty H,Srivastava A,Antoine DJ,Naisbitt D,Williams DP

更新日期：2011-06-30 00:00:00

abstract：:The Toxic Oil Syndrome (TOS) was an epidemic disease appeared in central Spain in 1981, causing over 400 deaths and affecting more than 20,000 people, mainly women and children. The disease was linked to the consumption of rapeseed oil denatured with aniline, illegally refined at the ITH oil refinery in Seville, mixed...

journal_title：Chemico-biological interactions

authors： Messeguer A

更新日期：2011-06-30 00:00:00

abstract：:The goal of this research was to test the hypothesis that bioactivation reactions could be exploited to deliver and activate mitochondria-targeted antioxidant prodrugs. The concept that bioactivation reactions could be used for prodrug delivery and activation has received little attention. Most bioactivation reactions...

journal_title：Chemico-biological interactions

authors： Anders MW

更新日期：2011-06-30 00:00:00

abstract：:Because of the inability to predict and quantify the risk of idiosyncratic adverse drug reactions (IADRs) and because reactive metabolites (RMs) as opposed to the parent molecules from which they are derived are thought to be responsible for the pathogenesis of some IADRs, procedures (RM trapping/covalent binding) are...

journal_title：Chemico-biological interactions

authors： Kalgutkar AS

更新日期：2011-06-30 00:00:00

abstract：:NADP(H)-dependent cytosolic aldo-keto reductases (AKR) are mostly monomeric enzymes which fold into a typical (α/β)(8)-barrel structure. Substrate specificity and inhibitor selectivity are determined by interaction with residues located in three highly variable loops (A, B, and C). Based on sequence identity, AKR have...

journal_title：Chemico-biological interactions

authors： Ruiz FX,Moro A,Gallego O,Ardèvol A,Rovira C,Petrash JM,Parés X,Farrés J

更新日期：2011-05-30 00:00:00

abstract：:Aldose reductase (AKR1B1), which catalyzes the reduction of glucose to sorbitol and lipid aldehydes to lipid alcohols, has been shown to be involved in secondary diabetic complications including cataractogenesis. Rats have high levels of AKR1B1 in lenses and readily develop diabetic cataracts, whereas mice have very l...

journal_title：Chemico-biological interactions

authors： Reddy AB,Tammali R,Mishra R,Srivastava S,Srivastava SK,Ramana KV

更新日期：2011-05-30 00:00:00

abstract：:Little is known about the roles of aldehyde dehydrogenases in non-vertebrate animals. We recently showed that in Drosophila melanogaster, an enzyme with ∼70% amino acid identity to mammalian ALDH2 is necessary for detoxification of dietary ethanol. To investigate other functions of this enzyme, DmALDH, encoded by the ...

journal_title：Chemico-biological interactions

authors： Chakraborty M,Fry JD

更新日期：2011-05-30 00:00:00

abstract：:Aldehyde dehydrogenase 2 (ALDH2) catalyzes oxidation of toxic aldehydes to carboxylic acids. Physiologic levels of Mg(2+) ions influence ALDH2 activity in part by increasing NADH binding affinity. Traditional fluorescence measurements monitor the blue shift of the NADH fluorescence spectrum to study ALDH2-NADH interac...

journal_title：Chemico-biological interactions

authors： Gonnella TP,Leedahl TS,Karlstad JP,Picklo MJ

更新日期：2011-05-30 00:00:00

abstract：:Anthracyclines (ANTs) are widely used in the treatment of various forms of cancer. Although their usage contributes to an improvement in life expectancy, it is limited by severe adverse effects-acute and chronic cardiotoxicity. Several enzymes from both AKR and SDR superfamilies have been reported as participants in t...

journal_title：Chemico-biological interactions

authors： Skarka A,Skarydová L,Stambergová H,Wsól V

更新日期：2011-05-30 00:00:00

abstract：:Human carbonyl reductases 1 and 3 (CBR1 and CBR3) are monomeric NADPH-dependent enzymes of the short-chain dehydrogenase/reductase superfamily. Despite 72% identity in primary structure they exhibit substantial differences in substrate specificity. Recently, the endogenous low molecular weight S-nitrosothiol S-nitroso...

journal_title：Chemico-biological interactions

authors： Staab CA,Hartmanová T,El-Hawari Y,Ebert B,Kisiela M,Wsol V,Martin HJ,Maser E

更新日期：2011-05-30 00:00:00

abstract：:The stereospecific 5β-reduction of Δ(4)-3-ketosterols is very difficult to achieve chemically and introduces a 90° bend between ring A and B of the planar steroid. In mammals, the reaction is catalyzed by steroid 5β-reductase, a member of the aldo-keto reductase (AKR) family. The human enzyme, AKR1D1, plays an essenti...

journal_title：Chemico-biological interactions

authors： Mindnich R,Drury JE,Penning TM

更新日期：2011-05-30 00:00:00

abstract：:4-Hydroxy-2-nonenal (HNE), a major reactive product of lipid peroxidation, is believed to play a central role in atherogenic actions triggered by oxidized lipoproteins. An aldo-keto reductase (AKR) 1C15 efficiently reduces HNE and is distributed in many rat tissues including endothelial cells. In this study, we invest...

journal_title：Chemico-biological interactions

authors： Matsunaga T,Shinoda Y,Inoue Y,Endo S,El-Kabbani O,Hara A

更新日期：2011-05-30 00:00:00

abstract：:Human 17β-hydroxysteroid dehydrogenase (17β-HSD) type 1 is an enzyme that acts at the pre-receptor level. It catalyzes the NADPH-dependent reduction of the weak estrogen estrone into the most potent estrogen 17β-estradiol, which exerts proliferative effects via estrogen receptors. Overexpression of 17β-HSD type 1 in e...

journal_title：Chemico-biological interactions

authors： Starčević S,Kocbek P,Hribar G,Rižner TL,Gobec S

更新日期：2011-05-30 00:00:00

abstract：:Risperidone has been used in some stress disorders and may be potentially protective against stress-induced gastric lesions. Thus, the aim of the present study is to investigate, whether risperidone, a D(2) receptor and 5-HT(2A) receptor antagonist, would be able to result in gastroprotective effect in stress-induced ...

journal_title：Chemico-biological interactions

authors： Saxena B,Krishnamurthy S,Singh S

更新日期：2011-04-25 00:00:00

abstract：:Numerous reactive oxygen species (ROS) and reactive carbonyl species (RCS) issuing from lipid and sugar oxidation are known to damage a large number of proteins leading to enzyme inhibition and alteration of cellular functions. Whereas studies in literature only focus on the reactivity of one or two of these compounds...

journal_title：Chemico-biological interactions

authors： Lesgards JF,Gauthier C,Iovanna J,Vidal N,Dolla A,Stocker P

更新日期：2011-03-15 00:00:00

abstract：:Copper is an essential trace metal for physiological functions, whereas copper overload causes cytotoxicity in living organisms. Genetically determined systems regulate acquisition, distribution and storage for copper maintenance and homeostasis. The Human ATP7A copper transport ATPase modulates intracellular copper d...

journal_title：Chemico-biological interactions

authors： Chen HR,Yang HC,Hsieh DJ,Liu Z,Tsai KJ

更新日期：2011-02-01 00:00:00

abstract：:Diabetes mellitus causes derangement of carbohydrate, protein and lipid metabolism which eventually leads to a number of secondary complications. Terminalia bellerica is widely used in Indian medicine to treat various diseases including diabetes. The present study was carried out to isolate and identify the putative a...

journal_title：Chemico-biological interactions

authors： Latha RC,Daisy P

更新日期：2011-01-15 00:00:00

abstract：:Increased oxidative stress and impaired antioxidant defense mechanism are important factors in the pathogenesis and progression of diabetes mellitus and other oxidant-related diseases. The present study was undertaken to evaluate the possible protective effects of S-allyl cysteine (SAC) against oxidative stress in str...

journal_title：Chemico-biological interactions

authors： Saravanan G,Ponmurugan P

更新日期：2011-01-15 00:00:00

abstract：:Tumor cells are able to survive and proliferate in spite of their increased oxidative stress. This was taken as a hint for the implication of oxidants/antioxidants in the proliferation of glial-tumor cells. In the present study, an anti-proliferative effect of Naringenin, an antioxidant against cerebrally implanted C6...

journal_title：Chemico-biological interactions

authors： Sabarinathan D,Mahalakshmi P,Vanisree AJ

更新日期：2011-01-15 00:00:00

abstract：:Human galactokinase (GALK) is the first enzyme in the Leloir pathway, converting α-d-galactose into galactose-1-phosphate (Gal-1-P). Recently, there is increasing interest in targeting GALK as a novel therapy to ameliorate the disease manifestations in patients with Classic Galactosemia as it would, in combination wit...

journal_title：Chemico-biological interactions

authors： Tang M,Wierenga K,Elsas LJ,Lai K

更新日期：2010-12-05 00:00:00

abstract：:Many benzo[b]furan lignans are known to be biologically active in nature. 2-(3'-Methoxy-4'-hydroxy-phenyl)-5-(3-hydroxypropyl)-7-methoxy-benzo[b]furan-3-carbaldehyde (XH-14) is found as a bioactive component isolated from the plant Salvia miltiorrhiza, commonly known as Danshen, which is a traditional Chinese medicine...

journal_title：Chemico-biological interactions

authors： Sung HY,Jun JG,Kang SW,Kim HS,Shin D,Kang IJ,Kang YH

更新日期：2010-12-05 00:00:00

abstract：:Methylmercury is a widely distributed environmental toxicant with detrimental effects on the developing and adult nervous system. Due to its accumulation in the food chain, chronic exposure to methylmercury via consumption of fish and sea mammals is still a major concern for human health, especially developmental expo...

journal_title：Chemico-biological interactions

authors： Ceccatelli S,Daré E,Moors M

更新日期：2010-11-05 00:00:00

abstract：:The human T-cell leukemia virus type I (HTLV-1) is the causative agent of adult T-cell leukemia (ATL), an aggressive CD4-positive T-cell neoplasia. The HTLV-1 proto-oncogene Tax, a potent transcriptional activator of cellular and viral genes, is thought to play a pivotal role in the transforming properties of the viru...

journal_title：Chemico-biological interactions

authors： Chlichlia K,Khazaie K

更新日期：2010-11-05 00:00:00

abstract：:Iron and copper ions, in their unbound form, may lead to the generation of reactive oxygen species via Haber-Weiss and/or Fenton reactions. In addition, it has been shown that copper ions can irreversibly and non-specifically bind to thiol groups in proteins. This non-specific binding property has not been fully addre...

journal_title：Chemico-biological interactions

authors： Letelier ME,Sánchez-Jofré S,Peredo-Silva L,Cortés-Troncoso J,Aracena-Parks P

更新日期：2010-10-06 00:00:00

abstract：:Vascular disease is a major cause of morbidity and mortality among transplanted recipients and cyclosporine (CsA) treatment has been consistently implicated in this event. In this study we assessed total blood homocysteine levels (tHcy), ecto-nucleotidase activities and adenine nucleotide/nucleoside levels searching f...

journal_title：Chemico-biological interactions

authors： Böhmer AE,Brum LM,Souza DG,Corrêa AM,Oses JP,Viola GG,Saraiva PJ,Driemeier D,Portela LV,Souza DO

更新日期：2010-10-06 00:00:00

abstract：:Methylglyoxal (MGO), a cytotoxic metabolite, is produced from glycolysis. Elevated levels of MGO are observed in a number of diabetic complications, including retinopathy, nephropathy and cardiomyopathy. Loss of retinal pericyte, a hallmark of early diabetic retinal changes, leads to the development of formation of mi...

journal_title：Chemico-biological interactions

authors： Kim J,Kim OS,Kim CS,Kim NH,Kim JS

更新日期：2010-10-06 00:00:00

abstract：:By rapid hydrolysis of the neurotransmitter, acetylcholine, acetylcholinesterase terminates neurotransmission at cholinergic synapses. Acetylcholinesterase is a very fast enzyme, functioning at a rate approaching that of a diffusion-controlled reaction. The powerful toxicity of organophosphate poisons is attributed pr...

journal_title：Chemico-biological interactions

authors： Dvir H,Silman I,Harel M,Rosenberry TL,Sussman JL

更新日期：2010-09-06 00:00:00

abstract：:The goal of this study was to assess acetylcholinesterase (AChE) inhibition at different regions of the gastrointestinal (GI) tract following inhalation exposure to nerve agent sarin. Seven major regions of the GI tract were removed from saline control animals (n=3) and 677.4 mg/m(3) sarin-exposed animals at 4h (n=4) ...

journal_title：Chemico-biological interactions

authors： Chanda S,Song J,Rezk P,Sabnekar P,Doctor BP,Sciuto AM,Nambiar MP

更新日期：2010-09-06 00:00:00

abstract：:The combined quantum mechanical-molecular mechanical (QM/MM) based computational scheme for modeling the structure-reaction rate correlations was elaborated for the hydrolysis of the set of neutral esters in the active site of acetylcholinesterase (AChE). The energy barriers of hydrolysis were estimated on the basis o...

journal_title：Chemico-biological interactions

authors： Lushchekina SV,Nemukhin AV,Morozov DI,Varfolomeev SD

更新日期：2010-09-06 00:00:00

abstract：:Novel therapeutics to overcome the toxic effects of organophosphorus (OP) chemical agents are needed due to the documented use of OPs in warfare (e.g. 1980-1988 Iran/Iraq war) and terrorism (e.g. 1995 Tokyo subway attacks). Standard OP exposure therapy in the United States consists of atropine sulfate (to block muscar...

journal_title：Chemico-biological interactions

authors： Demar JC,Clarkson ED,Ratcliffe RH,Campbell AJ,Thangavelu SG,Herdman CA,Leader H,Schulz SM,Marek E,Medynets MA,Ku TC,Evans SA,Khan FA,Owens RR,Nambiar MP,Gordon RK

更新日期：2010-09-06 00:00:00